Antineoplastic activity of idazoxan hydrochloride
نویسندگان
چکیده
منابع مشابه
Serine deprivation enhances antineoplastic activity of biguanides.
Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. There are ongoing clinical trials to evaluate its antitumor properties, which may relate to its fundamental activity as an inhibitor of oxidative phosphorylation. Here, we show that serine withdraw...
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Lonidamine (LND) was initially introduced as an antispermatogenic agent. It was later found to have anticancer activity sensitizing tumors to chemo-, radio-, and photodynamic-therapy and hyperthermia. Although the mechanism of action remained unclear, LND treatment has been known to target metabolic pathways in cancer cells. It has been reported to alter the bioenergetics of tumor cells by inhi...
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possible cancer chemotherapeutic agents. Howeven, pre himinary data indicate that these compounds are toxic and are not effective in humans (4, 14). In order to develop an effective chemothemapeutic agent for which the mode of action is inhibition of nibonucleotide meductase activity, a number of ahiphatic and aromatic hydroxamic acids and their corresponding amides and esters were synthesized ...
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Anti bacterial activities of several „non-antibiotic drugs‟ used in treatment of a variety of noninfectious human diseases have been observed. Such an effect has been noticed for barbiturates, beta-adrenergic receptor antagonists, diuretic drugs, H1 antihistamines, mucolytic agents, non-steroidal anti-inflammatory drugs, proton pump inhibitors and psychotherapeutic drugs. A synergic or antagoni...
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BACKGROUND Often potentially good chemotherapeutic drugs find limited clinical use due to the many negative medical and physical side-effects they may exhibit. To combat these negative side-effects, new antineoplastic materials are continuously being synthesised and evaluated. Ferrocene-containing compounds under certain conditions may show appreciable anticancer activity. Some of the factors t...
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ژورنال
عنوان ژورنال: Cancer Chemotherapy and Pharmacology
سال: 2009
ISSN: 0344-5704,1432-0843
DOI: 10.1007/s00280-009-0978-9